If you’re looking into GLP-1 medications for weight loss, you’ve probably come across two big names: semaglutide and tirzepatide.
So… what’s the difference?
And which one is better?
Let’s break it down.
How They Work
Semaglutide copies a hormone called GLP-1.
Tirzepatide copies two hormones: GLP-1 and GIP.
Both help you:
- Feel full faster
- Stay full longer
- Eat less without fighting cravings
- Keep your blood sugar more steady
Tirzepatide may have an edge because of the added GIP action, which might help even more with blood sugar and fat loss.
Effectiveness
In head-to-head studies, people on tirzepatide lost more weight than those on semaglutide — especially at higher doses.
But both are very effective, and many patients do great on either.
Side Effects
Both medications can cause:
- Nausea
- Constipation
- Reflux
- Fatigue in the beginning
Tirzepatide may cause a bit more nausea for some people, but it also seems to be better tolerated in others. It depends on your body.
Cost
Brand-name versions of both drugs are expensive — often over $1,000/month without insurance.
At New Leaf, we offer both brand name medications for those with insurance coverage, and compounded versions that are often more affordable and available for direct delivery.
The cost per vial depends on your dose, but we break everything down by cost per month, so you can compare fairly.
So… which one is better?
That depends on you. We prescribe both medications and help you choose based on your symptoms, dose needs, budget, and how your body responds.
Want more? Our patients get access to a full article comparing tirzepatide and semaglutide in more detail — including who tends to do better on which one, how to switch safely, and how to get the most from either.
