If you’re a woman in your 40s or 50s trying to lose weight and manage hormonal chaos, you’ve probably wondered:
“Can I do both GLP-1s and bioidentical hormone replacement therapy (BHRT)?”
Yes. Yes, you absolutely can. In fact, they often work better together.
Here’s why:
Hormones and Weight Are Besties (Whether We Like It or Not)
When estrogen, progesterone, and testosterone levels drop — hello, perimenopause and menopause — your metabolism slows, your appetite changes, and fat storage (especially around the belly) increases.
That means even if you’re doing “everything right,” the weight doesn’t budge. Or it comes off painfully slow.
BHRT helps correct those imbalances so your body isn’t working against you.
GLP-1s Target a Different Problem
Medications like semaglutide and tirzepatide help regulate appetite, stabilize blood sugar, and improve insulin sensitivity.
So while BHRT helps your hormonal foundation, GLP-1s help with cravings, overeating, and blood sugar swings — which often go haywire during hormone shifts.
Together, They’re a Power Combo
- BHRT supports your mood, energy, sleep, and metabolism.
- GLP-1s help with appetite, insulin resistance, and fat loss.
- Together? You feel like yourself again — and your body finally starts to cooperate.
At New Leaf, we specialize in both. Our Thrive and BHRT Programs combine weight loss and hormone therapy for women who are ready to feel in control again.
Want more? Our patients get access to a full-length article covering exactly how we combine BHRT with GLP-1s, which symptoms to look for, and what to expect when you’re doing both.
