Let’s get straight to it:
If you’re taking a GLP-1 medication like semaglutide or tirzepatide, can you still enjoy the occasional glass of wine or margarita?
Technically, yes. But there’s more to the story.
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Alcohol + GLP-1s: What You Need to Know
GLP-1 medications slow down digestion and reduce appetite. Alcohol does… the opposite of that.
Here’s what can happen when the two mix:
- Nausea or vomiting (especially on higher doses)
- Reflux or bloating
- Dizziness or feeling faint (especially if you’re not eating much)
- Low blood sugar, especially if you’re skipping meals
Plus, alcohol can interfere with your ability to make good food choices. (Ever eaten half a pizza after one glass of wine? Exactly.)
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Does It Cancel Out the Medication?
Not exactly — but drinking can:
- Trigger cravings
- Lower your inhibitions
- Add empty calories
- Stall your progress if it becomes routine
If you’re drinking frequently or heavily, your results will be affected.
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Best Practices If You Choose to Drink
- Wait until you’re stable on your dose (at least 4–6 weeks in)
- Eat before you drink to avoid nausea or dizziness
- Drink slowly and in moderation
- Avoid sugary mixers and high-calorie cocktails
- Skip alcohol on days you’re already feeling off
At New Leaf, we’re not the fun police — we’re just here to help you get the results you want while still enjoying life.
Want more? Our patients get access to a full article breaking down exactly how alcohol affects your GLP-1 medication, how to enjoy drinks without derailing your progress, and what to avoid at all costs.